In Adventures of Power, a critically acclaimed comedy about air-drumming released in 2008, Lynch reunited with Michael Mc Kean, her former co-star from For Your Consideration, in the role of Aunt Joanie and starring alongside Ari Gold, Adrian Grenier, Chiu Chi Ling, and Shoshannah Stern.
In a role similar to that of her contributions as Sue Sylvester on the Fox musical comedy-drama series Glee, Lynch's role as the encouraging Aunt Joanie to Power, a young musician who plays the air drums because he never had access to musical instruments, promotes the initiative to support music education.
She then continued to hone her comical and improvisational skills at Annoyance Theater, playing Carol Brady in the theater's The Real Live Brady Bunch.
Andy Richter played Mike Brady in the New York shows. During the 1990s, she made numerous television commercials, including one for Frosted Flakes for an adult audience, directed by Christopher Guest.
A few years later, Guest would remember Lynch, as he chose actors for his 2000 dog show mockumentary, Best in Show.
Lynch played Christy Cummings, a butch lesbian personal dog handler to trophy wife Sheri Ann Cabot (Jennifer Coolidge).
From there, she became a staple actress in Guest's casts, appearing in the director's A Mighty Wind (2003) as porn actress-turned-folk singer Laurie Bohner and in For Your Consideration (2006) as an entertainment reporter.
Audiences and critics took notice of Lynch for her turn in Judd Apatow's The 40-Year-Old Virgin.She told Fresh Air's Terry Gross that the role was originally intended for a man but also that, at the urging of Steve Carell's wife Nancy Walls, was offered to Lynch instead.Beginning from there, she took supporting roles in a series of films including Role Models, Talladega Nights: The Ballad of Ricky Bobby, Alvin & the Chipmunks, Walk Hard: The Dewey Cox Story, Space Chimps, The Rocker, The Hammer, Another Cinderella Story, Ice Age: Dawn of the Dinosaurs, Wreck-It Ralph, and Spring Breakdown.Lynch's television cameos include an appearance in the Nickelodeon situation comedy i Carly and the Showtime dark comedy series Weeds. situation comedy Two and a Half Men since 2004 and was nominated for a Primetime Emmy Award for her performance in 2010.She has also had other notable roles in numerous mainstream comedies, such as Talladega Nights: The Ballad of Ricky Bobby, The 40-Year-Old Virgin, Role Models and The Three Stooges.Her portrayal of Sue Sylvester in Glee has won numerous awards, including the Primetime Emmy Award, Golden Globe Award, Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Comedy Series, TCA Award for Individual Achievement in Comedy, Satellite Award for Best Supporting Actress – Series, Miniseries, or Television Film, and the People's Choice Award for Favorite TV Comedy Actress.