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Direct-to-consumer-advertising (DCTA) campaigns, which have expanded the size of the antidepressant market (Donohue et al., 2004), revolve around the claim that SSRIs (the most popular class of antidepressants) alleviate depression by correcting a deficiency of serotonin in the brain.

For example, Pfizer’s television advertisement for Zoloft states that “depression is a serious medical condition that may be due to a chemical imbalance”, and that “Zoloft works to correct this imbalance.”Other SSRI advertising campaigns make similar claims.

The Effexor website even has a slick video explaining that “research suggests an important link between depression and an imbalance in some of the brain’s chemical messengers.

Two neurotransmitters believed to be involved in depression are serotonin and norepinephrine.” The video goes on to explain that Effexor works by increasing serotonin levels in the synapse, which is “believed to relieve symptoms of depression over time.”These days serotonin is widely promoted as the way to achieve just about every personality trait that is desirable, including self-confidence, creativity, emotional resilience, success, achievement, sociability and high energy. Low serotonin levels have been implicated in almost every undesirable mental state and behavioral pattern, such as depression, aggressiveness, suicide, stress, lack of self-confidence, failure, low impulse control, binge eating and other forms of substance abuse.

In fact, the idea that low levels of serotonin cause depression has become so widespread that it’s not uncommon to hear people speak of the need to “boost their serotonin levels” through exercise, herbal supplements or even sexual activity.

The “chemical imbalance” theory is so well established that it is now part of the popular lexicon. It takes a complex and heterogeneous condition (depression) and boils it down to a simple imbalance of two to three neurotransmitters (out of more than 100 that have been identified), which, as it happens, can be “corrected” by long-term drug treatment.This clear and easy-to-follow theory is the driving force behind the billion worth of antidepressant drugs sold each year.However, there is one (rather large) problem with this theory: there is absolutely no evidence to support it.Recent reviews of the research have demonstrated no link between depression, or any other mental disorder, and an imbalance of chemicals in the brain (Lacasse & Leo, 2005; (Valenstein, 1998).The ineffectiveness of antidepressant drugs when compared to placebo cast even more doubt on the “chemical imbalance” theory.(See my recent articles Placebos as effective as antidepressants and A closer look at the evidence for more on this.)Folks, at this point you might want to grab a cup of tea.


  1. Der sorglose Umgang mit persönlichen Informationen in sozialen Netzwerken kann zu Konflikten in der Partnerschaft führen. Rolf Merkle, Psychotherapeut Ein neuer Begriff macht die Runde. Während wir Eifersucht im täglichen Leben fast alle kennen, so stellt sich manchem von uns vielleicht die Frage, was wir uns unter digitaler Eifersucht vorstellen sollen.

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